Clin Endocrinol. Download references. You can also search for this author in PubMed Google Scholar. Correspondence to Tim I. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and Permissions. Korevaar, T. The upper limit for TSH during pregnancy: why we should stop using fixed limits of 2. Thyroid Res 11, 5 Download citation. Received : 30 August Accepted : 30 April Published : 21 May Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Abstract Physiological changes necessitate the use of pregnancy-specific reference ranges for TSH and FT4 to diagnose thyroid dysfunction during pregnancy.
Background Thyroid physiology changes during pregnancy and this necessitates the use of pregnancy-specific reference ranges for TSH and FT4 in order to adequately diagnose gestational thyroid disease [ 1 ].
The ATA guidelines [ 9 ] now recommend the following: 1 Calculate pregnancy-specific and lab-specific references ranges for TSH and FT4 2 If 1 is not possible, adopt a reference range from the literature that is derived using a similar assay and preferably also in a population with similar characteristics i.
Patient Publications. Connect with Us. Patient Calendar of Events. Find a Thyroid Specialist. Am J Obstet Gynecol. Download references. We gratefully acknowledge all the participants in our study. The funders had no role in the design of study, data collection and analysis, or presentation of the results.
All data generated or analyzed during this study are available from the corresponding author on reasonable request. You can also search for this author in PubMed Google Scholar.
PL conceived the idea for the research, wrote the framework, and drafted the manuscript as the principal author. SL participated in the design of the study and performed the statistical analysis.
LL made substantial contributions to the study conception and framework and design. SSZ made substantial contributions to the study conception and framework. JHC made substantial contributions to the study conception and framework.
JHF was responsible for the data analysis and revision of the paper. All authors read and approved the final manuscript. Correspondence to Jianhui Fan. Written informed consent to participation was obtained from all participants, using a formulary approved by the Ethics Committee. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Reprints and Permissions. Li, P. Effect of mildly elevated thyroid-stimulating hormone during the first trimester on adverse pregnancy outcomes. BMC Endocr Disord 18, 64 Download citation.
Received : 12 February Accepted : 03 September Published : 12 September Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.
Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Abstract Background To investigate the effect of a mildly elevated thyroid-stimulating hormone TSH concentration between 2.
Results Among the study participants, the Conclusion A mildly elevated TSH concentration 2. Background Thyroid diseases are common endocrine disorders among women of reproductive age [ 1 ], and the serum concentration of thyroid-stimulating hormone TSH is the most commonly used index for evaluating thyroid function during pregnancy. Data collection Serum samples were obtained in the morning after an 8-h fast from all study participants during the first trimester. Statistical analysis Data are presented as mean standard deviation [SD] for normally distributed data, as median interquartile range for non-normally distributed data, and as frequency percentage for categorical variables.
A total of , pregnant women who had a TSH level between 0. These patients were divided into 3 groups: TSH level of 0. The rate of pregnancy complications like miscarriage, premature delivery and caesarean delivery, as well as birth weight of their newborn compared between these groups.
The results showed, as compared with mothers with a TSH 0. This study shows that higher TSH levels before pregnancy, even when they are borderline high, may be associated with a higher rate of miscarriage, pregnancy loss, cesarean section and large infants.
0コメント